Frailty, chronic kidney disease and falls: A vicious circle
Fabio Fabbian1, Alfredo De Giorgi2, María Aurora Rodríguez Borrego3, Pablo Jesús López-Soto3
1Clinica Medica, Department of Medical Sciences, University Hospital of Ferrara, University of Ferrara, Italy
2Clinica Medica, Department of Internal Medicine, University Hospital of Ferrara, Italy
3Department of Nursing, Maimónides Biomedical Research Institute of Córdoba (IMIBIC), Reina Sofía University Hospital, Univesity of Cordoba

Article ID: 100033Z09FF2017

Address correspondence to:
Fabio Fabbian
MD, Clinica Medica, Department of Medical Science
University of Ferrara, Department of Medicine
Azienda Ospedaliero-Universitaria (AOU) of Ferrara
44124 Cona (Ferrara)

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Fabbian F, De Giorgi A, Rodríguez-Borrego AR, López-Soto PJ. Frailty, chronic kidney disease and falls: A vicious circle. J Case Rep Images Med 2017;3:14–17.


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  1. Zhang QL, Rothenbacher D. Prevalence of chronic kidney disease in population-based studies: Systematic review. BMC Public Health 2008 Apr 11;8:117.   [CrossRef]   [Pubmed]    Back to citation no. 1
  2. Plantinga LC. Socio-economic impact in CKD. Nephrol Ther 2013 Feb;9(1):1–7.   [CrossRef]   [Pubmed]    Back to citation no. 2
  3. Jha V, Wang AY, Wang H. The impact of CKD identification in large countries: The burden of illness. Nephrol Dial Transplant 2012 Oct;27 Suppl 3:iii32–8.   [CrossRef]   [Pubmed]    Back to citation no. 3
  4. Zecevic AA, Salmoni AW, Speechley M, Vandervoort AA. Defining a fall and reasons for falling: Comparisons among the views of seniors, health care providers, and the research literature. Gerontologist 2006 Jun;46(3):367–76.   [Pubmed]    Back to citation no. 4
  5. Chang JT, Ganz DA. Quality indicators for falls and mobility problems in vulnerable elders. J Am Geriatr Soc 2007 Oct;55 Suppl 2:S327–34.   [CrossRef]   [Pubmed]    Back to citation no. 5
  6. Centers for disease control and prevention (CDC). Fatalities and injuries from falls among older adults: United States, 1993-2003 and 2001–2005. MMWR Morb Mortal Wkly Rep 2006 Nov 17;55(45):1221–4.   [CrossRef]   [Pubmed]    Back to citation no. 6
  7. López-Soto PJ, De Giorgi A, Senno E, et al. Renal disease and accidental falls: A review of published evidence. BMC Nephrol 2015 Oct 29;16:176.   [CrossRef]   [Pubmed]    Back to citation no. 7
  8. Sutton JC, Standen PJ, Wallace WA. Patient accidents in hospital: Incidence, documentation and significance. Br J Clin Pract 1994 Mar–Apr;48(2):63–6.   [Pubmed]    Back to citation no. 8
  9. Krauss MJ, Nguyen SL, Dunagan WC, et al. Circumstances of patient falls and injuries in 9 hospitals in a midwestern healthcare system. Infect Control Hosp Epidemiol 2007 May;28(5):544–50.   [CrossRef]   [Pubmed]    Back to citation no. 9
  10. Krauss MJ, Evanoff B, Hitcho E, et al. A case-control study of patient, medication, and care-related risk factors for inpatient falls. J Gen Intern Med 2005 Feb;20(2):116–22.   [CrossRef]   [Pubmed]    Back to citation no. 10
  11. Shlipak MG, Stehman-Breen C, Fried LF, et al. The presence of frailty in elderly persons with chronic renal insufficiency. Am J Kidney Dis 2004 May;43(5):861–7.   [CrossRef]   [Pubmed]    Back to citation no. 11
  12. Odden MC, Chertow GM, Fried LF, et al. Cystatin C and measures of physical function in elderly adults: The health, aging, and body composition (HABC) study. Am J Epidemiol 2006 Dec 15;164(12):1180–9.   [CrossRef]   [Pubmed]    Back to citation no. 12
  13. Padilla J, Krasnoff J, Da Silva M, et al. Physical functioning in patients with chronic kidney disease. J Nephrol 2008 Jul–Aug;21(4):550–9.   [Pubmed]    Back to citation no. 13
  14. Wilhelm-Leen ER, Hall YN, Tamura MK, Chertow GM. Frailty and chronic kidney disease: The third national health and nutrition evaluation survey. Am J Med 2009 Jul;122(7):664–71.e2.   [CrossRef]   [Pubmed]    Back to citation no. 14
  15. Verghese J, Holtzer R, Lipton RB, Wang C. Quantitative gait markers and incident fall risk in older adults. J Gerontol A Biol Sci Med Sci 2009 Aug;64(8):896-901.   [CrossRef]   [Pubmed]    Back to citation no. 15
  16. Bowling CB, Sawyer P, Campbell RC, Ahmed A, Allman RM. Impact of chronic kidney disease on activities of daily living in community-dwelling older adults. J Gerontol A Biol Sci Med Sci 2011 Jun;66(6):689–94.   [CrossRef]   [Pubmed]    Back to citation no. 16
  17. Liu CK, Lyass A, Massaro JM, D'Agostino RB Sr, Fox CS, Murabito JM. Chronic kidney disease defined by cystatin C predicts mobility disability and changes in gait speed: The framingham offspring study. J Gerontol A Biol Sci Med Sci 2014 Mar;69(3):301–7.   [CrossRef]   [Pubmed]    Back to citation no. 17
  18. Guideline for the prevention of falls in older persons. American geriatrics society, British geriatrics society, and American academy of orthopaedic surgeons panel on falls prevention. J Am Geriatr Soc 2001 May;49(5):664–72.   [Pubmed]    Back to citation no. 18
  19. Porto Gautério D, Zortea B, Costa Santos SS, da Silva Tarouco B, Lopes MJ, João Fonseca C. Risk factors for new accidental falls in elderly patients at traumatology ambulatory center. Invest Educ Enferm 2015;33(1):35–43.   [CrossRef]   [Pubmed]    Back to citation no. 19
  20. Ambrose AF, Paul G, Hausdorff JM. Risk factors for falls among older adults: A review of the literature. Maturitas 2013 May;75(1):51–61.   [CrossRef]   [Pubmed]    Back to citation no. 20
  21. Manfredini R, Fabbian F, Pala M, et al. Time of occurrence of in-hospital falls: A systematic mini review. J Am Geriatr Soc 2012 Jun;60(6):1183–4.   [CrossRef]   [Pubmed]    Back to citation no. 21
  22. Rubenstein LZ. Falls in older people: Epidemiology, risk factors and strategies for prevention. Age Ageing 2006 Sep;35 Suppl 2:ii37-41.   [CrossRef]   [Pubmed]    Back to citation no. 22
  23. Rubenstein LZ, Josephson KR. The epidemiology of falls and syncope. Clin Geriatr Med 2002 May;18(2):141–58.   [Pubmed]    Back to citation no. 23
  24. March LM, Chamberlain AC, Cameron ID, et al. How best to fix a broken hip: Fractured neck of femur health outcomes project team. Med J Aust 1999 May 17;170(10):489–94.   [Pubmed]    Back to citation no. 24
  25. Abdelhafiz AH, Austin CA. Visual factors should be assessed in older people presenting with falls or hip fracture. Age Ageing 2003 Jan;32(1):26–30.   [CrossRef]   [Pubmed]    Back to citation no. 25
  26. Fleming J, Brayne C. Inability to get up after falling, subsequent time on floor, and summoning help: Prospective cohort study in people over 90. BMJ 2008 Nov 17;337:a2227.   [CrossRef]   [Pubmed]    Back to citation no. 26
  27. Salvà A, Bolíbar I, Pera G, Arias C. Incidence and consequences of falls among elderly people living in the community. Med Clin (Barc) 2004 Feb 14;122(5):172–6.   [CrossRef]   [Pubmed]    Back to citation no. 27
  28. Zijlstra GA, van Haastregt JC, van Eijk JT, van Rossum E, Stalenhoef PA, Kempen GI. Prevalence and correlates of fear of falling, and associated avoidance of activity in the general population of community-living older people. Age Ageing 2007 May;36(3):304–9.   [CrossRef]   [Pubmed]    Back to citation no. 28

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We are indebted to Mrs. Mauro Pasin from University of Ferrara, for his valuable and precious collaboration.

Author Contributions
Fabio Fabbian – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Alfredo De Giorgi – Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
María Aurora Rodríguez Borrego – Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Pablo Jesús López-Soto – Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
Conflict of interest
Authors declare no conflict of interest.
© 2017 Fabio Fabbian et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.