Case Report
 
Ocular proptosis as an initial presentation of neuroblastoma in infant: A rare case report
Marliyanti Nur Rahmah Akib1, Faridah Amien1, Halimah Pagarra1, Suliati P. Amir1, Ratih Natasha1
1Department of Ophthalmology, Faculty of Medicine, Hasanuddin University, Wahidin Sudirohusodo Hospital, Makassar

Article ID: 100005Z17MA2018
doi: 10.5348/100005Z17MA2018CR

Corresponding Author:
Marliyanti Nur Rahmah Akib
Department of Ophthalmology
Faculty of Medicine, Hasanuddin University
Wahidin Sudirohusodo Hospital, Makassa

Access full text article on other devices

  Access PDF of article on other devices

[HTML Abstract]   [PDF Full Text][Print This Article]
[Similar articles in PubMed][Similar articles in Google Scholar]



How to cite this article
Akib MNR, Amien F, Pagarra H, Amir SP, Natasha R. Ocular proptosis as an initial presentation of neuroblastoma in infant: A rare case report. J Case Rep Images Opthalmol 2018;1:100005Z17MA2018.


ABSTRACT

Introduction: Neuroblastoma is a neoplasm arising from the primordial neural crest cells that form the sympathetic nervous system. Orbital neuroblastoma is typically a metastatic tumor. Accounting for 10–15% of childhood tumors, neuroblastoma is the second most common orbital tumor in children, after rhabdomyosarcoma.Neuroblastoma can also develop anywhere along the sympathetic nervous system chain from the neck to the pelvis. Neuroblastoma occurs primarily in the abdomen in 60% cases but in 8% cases the tumour arises in the orbit where it arises from ciliary ganglion. Toreport a rare case of neuroblastoma with ocular proptosis as an initial presentation.

Case Report: A case of seven months old baby who presented with rapidly progressing proptosis within three months. A team of multidisciplinary specialists was conducted to manage the case. Computerized Tomography Scanner (CT Scan) showed visible heterogeneous lesions in retrobulbar region, extends from superior orbital fissure to optical chiasm with destruction of the surrounding bone. Histopathologic diagnosis of neuroblastoma was made. Subsequent medical evaluation including laboratory, chest X-ray, and whole body computed tomography showed no evidence of systemic involvement or metastasis. The child was subjected to chemotherapy, but due to late presentation the patient deceased after the first cycle of chemotherapy.

Conclusion: Neuroblastoma should be considered in the differential diagnosis of rapidly progressing proptosis in infant. Care must be taken to manage the case aggressively as delayed diagnosis and treatment in rapidly growing tumor would have led to death.

Keywords: Childhood orbital tumors, Neuroblastoma, Primary orbital neuroblastoma


[HTML Abstract]   [PDF Full Text]

Author Contributions
Marliyanti Nur Rahmah Akib – Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Faridah Amien – Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Halimah Pagarra – Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Suliati P. Amir – Substantial contributions to conception and design, Drafting the article and revising it critically for important intellectual content, Final approval of the version to be published
Ratih Natasha – Substantial contributions to conception and design, Drafting the article and revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of Submission
The corresponding author is the guarantor of submission.
Source of Support
None
Consent Statement
Written informed consent was obtained from the patient for publication of this case report.
Conflict of Interest
Author declares no conflict of interest.
Copyright
© 2018 Marlyanti Nur Rahmah et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.