Case Report
Matrix producing breast cancer with chondroid differentiation
Quratulain Zulfiqar Ali1, Lubna Mushtaque Vohra2
1Postgraduate Resident Trainee, Internal Medicine, Ziauddin University Hospital, Karachi, Sindh, Pakistan
2Assistant Professor, Department of Surgery and Oncology, Ziauddin University Hospital, Karachi, Sindh, Pakistan

Article ID: 100053Z10QA2018
doi: 10.5348/100053Z10QA2018CR

Corresponding Author:
Quratulain Zulfiqar Ali
Flat Number 407, Adenwala Apartments
Britto Road, Garden East
Karachi, Sindh, Pakistan 74550

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How to cite this article
Ali QZ, Vohra LM. Matrix producing breast cancer with chondroid differentiation. J Case Rep Images Oncology 2018;4:100053Z10QA2018.


Introduction: A type of Metaplastic Breast Cancer (MBC) that has matrix producing properties is an infrequently occurring breast cancer and is responsible for less than 1% of the overall cases. MBC is mixed in nature, comprising of a blend of adenocarcinomatous and metaplastic components. The occurrence of MBC with chondroid differentiation is rarer and also a diagnostic challenge; warranting its presentation.

Case Report: A case of a 57-year-old female is reported here, having a 4.3x3.3 cm mass palpable at the lower outer quadrant of the right breast. Upon performing a trucut biopsy, an infiltrating malignant tumor was found, with focal chondroid differentiation in the background of a chondromyxoid matrix suggesting a metaplastic carcinoma.

Conclusion: Early detection and treatment is of key significance as Metaplastic Breast Cancer is a rare entity with a histopathological variance, a higher rate of metastasis, locally recurrent and carry an overall poor prognosis.

Keywords: Breast cancer, Chondroid, Metaplastic, Public health, Women’s health

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Author Contributions
Quratulain Zulfiqar Ali – Conception and design, Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Lubna Mushtaque Vohra – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of Submission
The corresponding author is the guarantor of submission.
Source of Support
Consent Statement
Written informed consent was obtained from the patient for publication of this case report.
Conflict of Interest
Author declares no conflict of interest.
© 2018 Quratulain Zulfiqar Ali et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.

About the Authors

Quratulain Zulfiqar Ali has worked as an FCPS Postgraduate Resident Trainee at Ziauddin University Hospital in the Department of Internal Medicine. She has graduated from Dow University of Health Sciences, Karachi, Pakistan in the year 2012.

Lubna Mushtaque Vohra is working as an Assistant Professor (Consultant Breast Surgeon) at Ziauddin University Hospital. MBBS from Dow Medical College Karachi FCPS from CPSP Karachi, Pakistan. I have published seven research papers in national and international journals. My keen area of interest is Breast Diseases, Cancer. I aspire to pursue further research in Breast cancer genetic mutations in our population.