Case Report
 
A case of squamous cell carcinoma of oral cavity treated with radical radiation in a patient with Fanconi anemia
Ashwini Gopal1, Deleep Kumar Gudipudi2
1DMRT, DNB RT, Registrar, Department of Radiation Oncology, Basavatarakam Indo American Cancer Hospital and Research institute, Hyderabad, Telangana, India
2DNB RT, Consultant, Department of Radiation Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India

Article ID: 100046Z10AG2017
doi: 10.5348/Z10-2017-45-CR-16

Corresponding Author:
Ashwini Gopal,
201, Sri Kuteer, Road no 8, Kakatheeya Hills,
Madhapur, Hyderabad, Telangana,
India, 500081

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How to cite this article
Gopal A, Gudipudi DK. A case of Squamous cell carcinoma of oral cavity treated with radical radiation in a patient with Fanconi anemia. J Case Rep Images Oncology 2017;3:69–72.


ABSTRACT
Introduction:Fanconi anemia is an autosomal or X-linked recessive disorder due to germ-line mutations in DNA repair genes. head and neck squamous cell carcinoma (HNSCC) is the most common solid tumor in Fanconi anemia, of which oral cavity tumors are the most common. Due to impaired DNA repair mechanism these patients will have higher treatment related toxicity with radiotherapy and chemotherapy and concurrent chemotherapy is not an option.
Case Report: We report a case of Fanconi anemia presented with carcinoma of oral cavity (Upper alveolus c T3 N0 M0), who was treated with radical radiation with reduced dose using volumetric modulated arc radiotherapy (VMAT i.e., rapid arc intensity modulated radiotherapy) with simultaneous integrated boost (SIB) with acceptable toxicity. She received 63.6 Gy to GTV, 54 Gy to high risk CTV, 49.5 Gy to low risk CTV in 30 fractions. She developed Grade II mucositis, Grade III fatigue, and Grade II skin reaction during the course of radiation. Patient is disease free and alive after 20 months of diagnosis.
Conclusion:Radical radiation with reduced dose can be used as effective treatment in patients with Fanconi anemia in carcinoma oral cavity with acceptable acute toxicity and good local control.

Keywords: Carcinoma oral cavity, Fanconi anemia, Radiation, Rapid arc IMRT


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Author Contributions
Ashwini Gopal – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Deleep Kumar Gudipudi – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of Submission
The corresponding author is the guarantor of submission.
Source of Support
None
Conflict of Interest
Authors declare no conflict of interest.
Copyright
© 2017 Ashwini Gopal et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.