Case Report
 
Primary diffuse large B cell lymphoma of the cervix presenting as bilateral hydronephrosis
Joel Alcid1, Christian Fidler2
1MD, Resident, Internal Medicine, Drexel, Philadelphia, PA, USA
2MD, Attending, Hematology Oncology, Abington-Jefferson Health, Abington, PA, USA

Article ID: 100040Z10JA2017
doi:10.5348/Z10-2017-40-CR-11

Address correspondence to:
Joel Alcid
Hahnemann University Hospital / Drexel Medicine
239 N Broad St, Philadelphia
PA, USA, 19102

Access full text article on other devices

  Access PDF of article on other devices

[HTML Full Text]   [PDF Full Text] [PDF Full Text] [Print This Article]
[Similar article in Pumed] [Similar article in Google Scholar]

How to cite this article
Alcid J, Fidler C. Primary diffuse large B cell lymphoma of the cervix presenting as bilateral hydronephrosis. J Case Rep Images Oncology 2017;3:48–51.


ABSTRACT
Introduction: Non-Hodgkin lymphoma (NHL) arises most frequently in lymph nodes or other lymphatic tissue. Primary lymphomas of the female reproductive tract are extremely rare, less than 1% of extra nodal NHL and <0.5% of gynecologic malignancies.
Case Report: We present a case of a 66-year-old postmenopausal female presented with a one month history of fatigue, dysuria and hematuria. A non-contrast computed tomography scan of abdomen and pelvis revealed a large ~7–9 cm mass involving the lower uterine segment/cervix displacing the rectosigmoid colon. Biopsy revealed it to be a CD 20 positive diffuse large B cell type non-Hodgkin lymphoma (NHL). She was diagnosed as stage IE and started on R-CHOP chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone).
Conclusion: Primary diffuse large B cell lymphoma of the female genital tract is a rare diagnosis and must be diagnosed early due to the aggressiveness of the tumor. There is no standard treatment regimen. Patients are often treated with chemotherapy as the first line of treatment, which has provided promising results.

Keywords: Cervix, Diffuse large B cell lymphoma, Non-Hodgkin’s lymphoma, Uterus


[HTML Full Text]   [PDF Full Text]

Author Contributions
Joel Alcid – Substantial contributions to conception and design, Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of version to be published
Christian Fidler – Substantial contributions to conception and design, Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2017 Joel Alcid et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.