Journal of

Case Reports and Images in Oncology

 
     
Case Report
 
Lymphoepithelial carcinoma of the larynx
Kouadir Asmaa1, EL Mazghi Abderrahmane2, Hassouni Khalid3
1Resident Doctor, Resident Doctor, Department of Radiotherapy Hassan II University Hospital, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
2Associate Professor, Department of Radiotherapy Hassan II University Hospital, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
3Professor and Head of the Department, Department of Radiotherapy Hassan II University Hospital, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco.

Article ID: 100033Z10KA2017
doi:10.5348/Z10-2017-33-CR-4

Address correspondence to:
Asmaa Kouadir
Bd urbain, Résidence Gourrama, 2ème étage
n°4, Zohour 2, FES, Maroc, FEZ
Morocco, 30060

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How to cite this article:
Kouadir A, El Mazghi A, Hassouni K. Lymphoepithelial carcinoma of the larynx. J Case Rep Images Oncology 2017;3:17–21.


Abstract
Introduction: Lymphoepithelial carcinoma of the larynx accounts only for 0.2% of all laryngeal cancers. These tumors are exceedingly rare and aggressive neoplasm. The relationship between Epstein–Barr virus (EBV) and laryngeal lymphoepithelial carcinoma remains controversial.
Case Report: Herein, we describe a case of 81-year-old male, with a chronic smoking history, presented with complaint of dysphonia over one year period. The evolution was marked by the occurrence of dysphagia and severe dyspnea requiring emergency tracheostomy. Computed tomography scan of the neck showed a mass involving the entire larynx associated to cervical adenopathies. Endoscopic examination confirmed the findings of an ulcerated lesion affecting the three parts of the larynx and extending to the base of the tongue as well as to the postcricoid region. A biopsy of the lesion has been performed. Histological examination and immunohistochemistry revealed lymphoepithelial carcinoma of the larynx. Screening for Epstein–Barr virus (EBV) by immunohistochemical examination was negative. As the tumor was considered inoperable, the patient was treated solely with radiation therapy.
Conclusion: Although rarely found in the larynx, it is essential to distinguish the lymphoepithelial carcinoma from squamous cell carcinoma. Immunohistochemistry must be the basis of the positive diagnosis. Epstein–Barr virus associated lymphoepithelial carcinoma has been exceptionally reported. This tumor is radiosensitive and radiotherapy should be considered as the main treatment.

Keywords: Epstein–Barr virus, Larynx, Lymphoepithelial carcinoma


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Author Contributions
Kouadir Asmaa – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
EL Mazghi Abderrahmane – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Hassouni Khalid – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2017 Kouadir Asmaa et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



About The Authors

Asmaa Kouadir is Resident doctor at Department of Radiotherapy, Hassan II University Hospital, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco. She earned undergraduate degree (MBBS) from Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco and postgraduate degree from Medical Doctor Degree from Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco. Her research interests include intensity modulated radiotherapy, and head and neck cancers. She intends to pursue a fellowship in radiation therapy after completing her residency.



Abderrahmane El Mazghi is Associate Professor at Department of Radiotherapy, Hassan II University Hospital, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco. He earned undergraduate degree (MBBS) from Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco and postgraduate degree (PhD) from Department of Radiotherapy, Hassan II University Hospital, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco. He has published 30 research papers in national and international academic journals. His research interests include sarcomas, brachytherapy, and lymphomas.



Khalid Hassouni is Head of Department and Director of Department of Radiotherapy at Hassan II University Hospital, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco. He earned the undergraduate degree (MBBS) from Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco and Postgraduate degree (PhD) from Department of Radiotherapy, National Institute of Oncology Sidi Mohamed Ben Abdellah, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco. He has published more than 100 research papers in national and international academic journals. His research interests include intensity modulated radiotherapy, brachytherapy, and head and neck cancers.




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