Journal of

Case Reports and Images in Oncology

 
     
Case Report
 
Primary melanoma of the vagina: A review of treatment strategies
Moulton L.1, Goodrich S.2, Rose P.G.2
1Ob/Gyn and Women's Health Institute, Cleveland Clinic, Cleveland, OH, USA.
2Gynecologic Oncology division, Ob/Gyn and Women's Health Institute, Cleveland Clinic, Cleveland, OH, USA.

Article ID: 100030Z10ML2017
doi:10.5348/Z10-2017-30-CR-1

Address correspondence to:
Moulton L.
Ob/Gyn and Women's Health Institute
9500 Euclid Ave- A81
Cleveland
OH 44195

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How to cite this article:
Moulton L, Goodrich S, Rose PG. Primary melanoma of the vagina: A review of treatment strategies. J Case Rep Images Oncology 2017;3:1–5.


Abstract
Introduction: Melanomas of the female lower genital tract are rare, but account for approximately 10% of melanomas diagnosed in women. The five-year survival rate for vaginal melanoma is low, approximating 18%. Due to the rarity of this disease and poor prognosis, there is limited information for evidence-based treatment strategies.
Case Report: This case report discusses the management of a patient diagnosed with primary vaginal melanoma treated with total pelvic exenteration with negative margins, followed by adjuvant chemotherapy with temozolomide and cisplatin. Six months following the completion of chemotherapy, the patient developed liver metastasis.
Conclusion: While adjuvant chemotherapy with temozolomide and cisplatin showed promise due to improved recurrence free survival compared to observation and high-dose interferon in patients with mucosal melanomas, further studies are needed to determine an effective adjuvant therapy regimen in patients with vaginal melanoma.

Keywords: Adjuvant, Chemotherapy, Exenteration, Melanoma, Pelvic, Vaginal


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Author Contributions
Moulton L. – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Goodrich S. – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Rose P.G. – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2017 Moulton L. et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



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