Journal of

Case Reports and Images in Oncology

 
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Case Report
 
Acute pancreatitis induced by cisplatin-etoposide regimen
Abdulqadir J. Nashwan1, Hind H. Elmalik2, Sindhumole L. K. Nair1, Mohamed A. Yassin3
1Nurse Educator, Hamad Medical Corporation – Nurse Educator, Department of Nursing Education & Research, National Center for Cancer Care and Research (NCCCR), Doha, Qatar.
2Oncology Consultant, Hamad Medical Corporation – Oncology Consultant, Department of Medical Oncology, National Center for Cancer Care and Research (NCCCR), Doha, Qatar.
3Hematology Consultant, Hamad Medical Corporation – Hematology Consultant, Department of Hematology and BMT, National Center for Cancer Care and Research (NCCCR), Doha, Qatar.

Article ID: 100024Z10AN2016
doi:10.5348/Z10-2016-24-CR-15

Address correspondence to:
Abdulqadir J. Nashwan
Hamad Medical Corporation
PO.Box 3050, Doha
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How to cite this article:
Nashwan AJ, Elmalik HH, Nair SLK, Yassin MA. Acute pancreatitis induced by cisplatin-etoposide regimen. J Case Rep Images Oncology 2016;2:61–65.


Abstract
Introduction: Drug-induced pancreatitis is less prevalent compared to other causes of acute pancreatitis, the incidence ranges between 0.1–2% of acute pancreatitis. Several reports are suggesting the association of pancreatitis with cisplatin but etoposide has not been reported to associate with pancreatitis.
Case Report: A 25-year-old, Filipino lady presented with Stage IV cervical cancer with neuroendocrine features. She was started on chemotherapy regimen of cisplatin and etoposide. She tolerated the six cycles of chemotherapy, and she was planned to start concurrent chemoradiation. However, due to persistently elevated levels of serum creatinine, she could not receive cisplatin. During radiotherapy, she has developed acute pancreatitis. The common causes of acute pancreatitis were ruled out; given the time course, it was assumed that the chemotherapeutic agents; cisplatin and etoposide might be suggested risk factors for the development of pancreatitis in our patient.
Conclusion: Early identification of acute pancreatitis helps in instituting effective treatment. Therefore, knowledge regarding acute pancreatitis related to cisplatin has utmost significance.

Keywords: Acute Pancreatitis, Cisplatin, Etoposide, Neuroendocrine cervical cancer


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Author Contributions
Abdulqadir J. Nashwan – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Hind H. Elmalik – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Sindhumole L. K. Nair – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Mohamed A. Yassin – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2016 Abdulqadir J. Nashwan et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



About The Authors

Abdulqadir Nashwan is a Nurse Educator at Department of Nursing Education and Research, National Center of Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar. He earned undergraduate degree (in Nursing Science) from The Hashemite University, Al-Zarqa, Jordan and postgraduate degree (Master of Nursing Oncology) from the same university. He completed a 12-month program in Cancer Biology and Therapeutics (CBT) from Harvard Medical School. He has published more than 30 research papers in national and international academic journals and authored one book. His research interests include hematology, oncology, research utilization, evidence-based practice, palliative care, and symptom management. He intends to pursue PhD in Nursing Oncology in future.



Hind Elmalik is an Oncology Consultant, Department of Medical Oncology at the National Center for Cancer Care and Research (NCCCR), and also a member of Hamad Medical Corporation (HMC) in Qatar.



Sindhumole LAK Nair is a Nurse Educator at Department of Nursing Education and Research, National Center of Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar. She earned the undergraduate degree (in Nursing Science) from Government College of Nursing, University of Kerala, Thiruvananthapuram, India and postgraduate degree (Master of Nursing Oncology) from the same university. She has published two research papers in national and international academic journals. Her research interests include hematology, oncology, palliative care, nursing science, evidence-based practice, and symptom management. She intends to pursue PhD in Nursing in future.



Mohamed Yassin is a Hematology Consultant, Department of Medical Oncology at the National Center for Cancer Care and Research (NCCCR), and also a member of Hamad Medical Corporation (HMC) in Qatar.




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