Journal of

Case Reports and Images in Oncology

 
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Case Report
 
Glassy cell carcinoma arising in the vagina: A case in a young patient
Maher Slimane1, Nada Belhaj Yahia2, Hanene Bouaziz2, Salma Gadria2, Monia Hechiche3, Khaled Rahal4
1Assistant, Oncologic Surgery Department, Institute Salah Azaiez, 1006 Tunis, Tunisia.
2Resident, Oncologic Surgery Department, Institute Salah Azaiez, 1006 Tunis, Tunisia.
3Professor, Oncologic Surgery department, Institute Salah Azaiez, 1006 Tunis, Tunisia.
4Department head, Oncologic Surgery Department, Institute Salah Azaiez, 1006 Tunis, Tunisia.

Article ID: 100016Z10MS2016
doi:10.5348/Z10-2016-16-CR-7

Address correspondence to:
Nada Belhaj Yahia
Oncologic Surgery Department: Institute Salah Azaiez
Boulevard 9 Avril, 1006
Tunis
Tunisia

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How to cite this article:
Slimene M, Belhaj Yahia N, Bouaziz H, Gadria S, Hechiche M, Rahal K. Glassy cell carcinoma arising in the vagina: A case in a young patient. J Case Rep Images Oncology 2016;2:28–31.


Abstract
Introduction: Glassy cell carcinoma is rare entity especially reported in cervix. Its occurrence in the vagina is exceptional. This article is the second known case of glassy cell carcinoma arising in the vagina. Extrapolating the results related to glassy cell carcinoma of the cervix and data on tumors of the vagina, has allowed us to better define the treatment of this tumor and predict its prognosis. In fact, glassy cells carcinoma is a histologically subtype of cancer known for its loco-regional aggressiveness and the high frequency of metastases. So, the treatment strategy should be discussed in a multidisciplinary meeting.
Case Report: A 24-year-old female patient presented with atypical genital bleeding for about six months and whose different explorations have concluded that it was glassy cell carcinoma arising in the vagina with clinical staging of 'International Federation of Obstetrics and Gynecology' III disease. This case illustrates the potential for glassy cell carcinoma to arise throughout the female genital tract but mainly through the lymphatic node. The patient was successfully treated by neoadjuvant chemotherapy and concomitant radio-chemotherapy proceeded by ovarian transposition. Despite the poor prognosis of this rare entity, after a decline of six months, there was a good therapeutic response with complete disappearance of the tumor.
Conclusion: The aggressiveness of the glassy cell carcinoma, rare tumor which can affect the vagina, makes the multidisciplinary management essential. Despite the combination of radiotherapy, chemotherapy and surgery in the treatment of these tumors, their prognosis remains poor.

Keywords: Adenosquamous carcinoma, Genital bleeding, Glassy cell carcinoma, Vaginal cancer


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Author Contributions
Maher Slimane – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Nada Belhaj Yahia – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Hanene Bouaziz – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Salma Gadria – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Monia Hechiche – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Khaled Rahal – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2016 Maher Slimane et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



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