Journal of

Case Reports and Images in Oncology

 
  Table of Contents    
Case Series
 
Glioblastoma multiforme: A pediatric case series
Marina S. Yacob1, Donna L. Johnston2
1B.Sc. Research Assistant, Division of Hematology Oncology, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
2MD, Pediatric Oncologist, Division of Hematology/Oncology, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.

Article ID: 100014Z10MY2016
doi:10.5348/Z10-2016-14-CS-5

Address correspondence to:
Donna L. Johnston
Division of Hematology/Oncology
Children's Hospital of Eastern Ontario 401 Smyth Road
Ottawa, ON
Canada K1H 8L1

Access full text article on other devices

  Access PDF of article on other devices

[HTML Full Text]   [PDF Full Text] [Print This Article]
[Similar article in Pumed] [Similar article in Google Scholar]

How to cite this article:
Yacob MS, Johnston DL. Glioblastoma multiforme: A pediatric case series. J Case Rep Images Oncology 2016;2:18–22.


Abstract
Introduction: Glioblastoma multiforme (GBM), the most aggressive malignant primary brain tumor, is uncommon in children accounting for only 3% of primary pediatric brain tumors. We reviewed a case series of five pediatric patients diagnosed at our institution over an 8-month period.
Case Series: Of the five pediatric GBMs, three were supratentorial, one was infratentorial and one was in the spinal cord. The diagnosis of GBM occurred at a mean age of 9.25 years and the male to female ratio was 3:2. The main presenting symptoms included headaches (60%), nausea and vomiting (40%) and limb weakness (40%). Four of five patients were treated with maximal surgical resection and radiation therapy. The majority also received chemotherapy with temozolomide and lomustine. All patients died of tumor progression with a median survival of 9.0 months following diagnosis.
Conclusion: Glioblastoma multiforme remains a very challenging tumor to treat in the pediatric population. Locally, the incidence of glioblastoma multiforme is increasing and further study needs to investigate if this is a national occurrence.

Keywords: Brain tumor, Glioblastoma multiforme, Oncology, Pediatric


[HTML Abstract]   [PDF Full Text]

Author Contributions:
Marina S. Yacob – Substantial contributions to conception and designs, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Donna L. Johnston – Substantial contributions to conception and designs, Acquisition of data, Analysis and interpretation of data, Revising the article critically for important intellectual content, Final approval of the version to be published

Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2016 Marina S. Yacob et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



  Home line About the Journal line Aim and Scope line Open Access line Archives
Apply as Editor line Apply as Reviewer line Submit Reviews - Editors line Submit Reviews - Reviewers
Instructions for Authors line Templates to Use line Copyright Form line Author Checklist
Online Submission line Email Submission line Submit Revision line Submit All Forms line Submit Page Proofs
Terms of Service line Privacy policy line Disclaimer line FAQ line Contact: Journal line Contact: Edorium Journals line Site Map
 
  Copyright © 2017. Edorium. All rights reserved.