Journal of

Case Reports and Images in Oncology

 
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Case Report
 
Rapid growth of massive retinal gliosis in an infant
Nobuhiko Shiraki1, Takeshi Morimoto1, Takashi Fujikado1, Kohji Nishida1
1Department of Ophthalmology, Osaka University Graduate School of Medicine.

Article ID: 100007Z10NS2015
doi:10.5348/Z10-2015-7-CR-7

Address correspondence to:
Takeshi Morimoto
Department of Ophthalmology
Osaka University Graduate School of Medicine

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How to cite this article:
Shiraki N, Morimoto T, Fujikado T, Nishida K. Rapid growth of massive retinal gliosis in an infant. J Case Rep Images Oncology 2015;1:28–31.


Abstract
Introduction: Massive retinal gliosis (MRG) is a rare, benign intraocular tumor that results from the proliferation of well-differentiated glial cells. MRGs develop because of a variety of causes.
Case Report: We encountered a case of a 2-year-old male infant with loss of vision in the right eye. Enucleation was carried out due to an absolute glaucoma. Histologically, the vitreous body had been totally replaced by massively proliferated spindle cells, which had delicate fibrillary cytoplasm without nuclear atypia. Immunohistochemically, the cells were strongly positive for glial fibrillary acidic protein. These findings led to a diagnosis of massive gliosis.
Conclusion: Massive retinal gliosis (MRG) is a rare, benign intraocular tumor that results from the proliferation of well-differentiated glial cells. To our knowledge, this may be the first report of such an occurrence in a 2-year- old infant. It is important for ophthalmologists to be suspicious of a mass resistant to chemotherapy that resembles a RB in children.

Keywords: Glavcoma, Infant tumor, Intraocular tumor, Massive retinal gliosis


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Author Contributions
Nobuhiko Shiraki – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Takeshi Morimoto – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Takashi Fujikado – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Kohji Nishida – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2015 Nobuhiko Shiraki et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



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