Journal of

Case Reports and Images in Oncology

 
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Case Report
 
Aggressive extraocular sebaceous carcinoma metastasizing to multiple visceral sites
Benjamin Presman1, Ilaria Tocco-Tussardi2, Lars Jørgensen3, Lene Birk-Sørensen1
1MD, Department of Plastic Surgery, Aalborg University Hospital, Aalborg, Denmark.
2MD, Department of Plastic Surgery, Uppsala University Hospital, Uppsala, Sweden.
3MD, Institute of Pathology, Vendyssel Hospital, Vendyssel, Denmark.

Article ID: 100006Z10BP2015
doi:10.5348/Z10-2015-6-CR-6

Address correspondence to:
Benjamin Presman
Bianco Lunos Alle 8
1 tv. Frederiksberg, Copenhagen
Denmark, 1868
Phone: +45 81 74 74 18

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How to cite this article:
Presman B, Tocco-Tussardi I, Jørgensen L, Birk-Sørensen L. Aggressive extraocular sebaceous carcinoma metastasizing to multiple visceral sites. J Case Rep Images Oncology 2015;1:23–27.


Abstract
Introduction: Extraocular sebaceous carcinoma (SC) is a rare neoplasm with only 130 previous reported cases. Traditionally, extraocular sebaceous carcinoma is considered less aggressive in comparison to the ocular type. However, recent studies show that extraocular SC may lead to widespread disseminated metastatic disease in 21% of cases.
Case Report: We report a case of a previously healthy man who developed extraocular sebaceous carcinoma on his lower back. A month later, the patient presented with hemoptysis, hip-, and abdominal pain. Magnetic resonance imaging confirmed the presence of lung, liver and bone metastases. The patient was initially misdiagnosed with squamous cell carcinoma, but immunohistochemistry concluded the correct diagnosis to be extraocular sebaceous carcinoma. The patient died shortly after diagnosis.
Conclusion: Our case supports the recent shift in paradigm of extraocular SC's ability to metastasize. Also, we review the current reported cases and show a 60% occurrence of lymph node involvement in the cases of metastasizing extraocular SC. These previous cases and the present case report confirm the need to consider either sentinel node biopsy or lymphadenectomy in the primary management of these patients.

Keywords: Extraocular, Metastasis, Sebaceous carcinoma, Squamous cell carcinoma


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Author Contributions
Benjamin Presman – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Ilaria Tocco-Tussardi – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Lars Jørgensen – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Lene Birk-Sørensen – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2015 Benjamin Presman et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



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