Journal of

Case Reports and Images in Oncology

 
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Case Report
 
Unicentric Castleman's disease: An unusual cause of neck swelling
Ashok S. Komaranchath1, A.H. Rudresh2, Kuntegowdenahalli Lakshmaiah C.3, Chennagiri S. Premalata4, Dasappa Loknatha5, Linu A. Jacob5
1DM Medical Oncology Resident, Dept. of Medical Oncology, Kidwai Memorial Institue of Oncology, Bangalore-29, India.
2Assistant Professor, Dept. of Medical Oncology, Kidwai Memorial Institue of Oncology, Bangalore-29, India.
3Professor and HOD, Department of Medical Oncology, Kidwai Memorial Institue of Oncology, Bangalore-29, India.
4Associate Professor, Dept. of Pathology, Kidwai Memorial Institue of Oncology, Bangalore-29, India.
3Associate Professor, Dept. of Medical Oncology, Kidwai Memorial Institue of Oncology, Bangalore-29, India.

Article ID: 100002Z10AK2015
doi:10.5348/Z10-2015-2-CR-2

Address correspondence to:
Dr. Ashok S Komaranchath
Department of Medical Oncology, Kidwai Memorial Insitute of Oncology
Dr. M. H. Marigowda Road, Bangalore – 560029
Karnataka
India
Phone: +919880565471

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How to cite this article:
Komaranchath AS, Rudresh AH, Lakshmaiah K C, Premalata CS, Lok;natha D, Jacob LA. Unicentric Castleman's disease: An unusual cause of neck swelling. J Case Rep Images Oncology 2015;1:5–9.


Abstract
Introduction: Castleman's disease is a rare disorder in which there is a benign proliferation of lymphoid tissue. There are two clinical entities namely, unicentric Castleman's disease with the disease confined to a single anatomic lymph node and a multicentric Castleman's disease characterized by generalized lymphadenopathy, constitutional symptoms, a more aggressive clinical course and relatively poorer prognosis. The most common histopathological subtype is the hyaline vascular variant.
Case Report: We present the case of an 18-year-old female presented with a painless right-sided neck swelling which was completely excised and diagnosed to have hyaline vascular variant of unicentric Castleman's disease. This disorder carries an excellent prognosis and does not require further therapy if complete excision of the involved lymph node has been done.
Conclusion: Unicentric Castleman's disease is a rare cause of unilateral neck swelling albeit with an excellent prognosis. Diagnosis by excision biopsy can double up as the treatment as well in cases of solitary lymph node involvement.

Keywords: Castleman's disease, Hyaline vascular variant, Immunocompetent, Unicentric


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Author Contributions
Ashok S. Komaranchath – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
A.H. Rudresh – Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Kuntegowdenahalli Lakshmaiah C. – Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Chennagiri S. Premalata – Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Dasappa Loknatha – Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Linu A. Jacob – Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2015 Ashok S. Komaranchath et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



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