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Case Reports and Images in Medicine

 
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Case Report
 
Efficacy of topical tetracyclines in Hailey-Hailey disease
Amarouch H.1, Ismaili N.1, Hassam B.1
1Department of Dermatology, University Hospital of IBN SINA Rabat Maroc.

Article ID: 100011Z09AH2016
doi:10.5348/Z09-2016-11-CR-4

Address correspondence to:
Amarouch Hajar
Department of Dermatology
University hospital of IBN SINA Rabat Maroc

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How to cite this article:
Amarouch H, Ismaili N, Hassam B. Efficacy of topical tetracyclines in Hailey-Hailey disease. J Case Rep Images Med 2016;2:12–14.


Abstract
Introduction: Familial benign chronic pemphigus or Hailey-Hailey disease (HHD) is a rare autosomal dominant disorder characterized by the development of recurrent blisters and erosions in the intertriginous areas. A variety of systemic and topical treatment options was used with a mixed results, including corticosteroids, topical zinc oxide, topical 5-fluorouracil, topical vitamin D analogs, dapsone, ultraviolet A, systemic retinoids, cyclosporine, methotrexate, and photodynamic therapy, laser therapy and botulinum toxin.
Case Report: We describe a case of HHD with a history of active hepatitis, which was successfully treated by topical tetracycline after only 2 weeks treatment.
Conclusion: This report is the first to describe an effect of topical tetracyclines in controlling the skin lesions in HHD.

Keywords: Autosomal dominant disorder, Blisters, Erosions, Familial benign chronic pemphigus, Hailey-Hailey disease, Topical tetracyclines


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Author Contributions
Amarouch H. – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Ismaili N. – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Hassam B. – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2016 Amarouch H. et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



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